You can’t call or text them because… well, you are in the middle of nowhere with no signal. Your buddies and you went hiking, but somehow you got off the trail, and don’t see them anymore. Imagine you are on a camping trip in the middle of nowhere. Yet, there are some situations when off-grid messaging apps can come in really handy. In a world where there is a free Wi-Fi signal at almost any corner, and cell phone coverage is so extensive, it might seem obsolete to even worry about offline messaging. □Looking for a more traditional way to broadcast your messages? Check out our guide about the WhatsApp Newsletter!įrom camping trips to political protests: when off-grid messaging comes in handy The other phones just act as signal amplifiers.Īside from P2P mode, you can also use gadgets to extend the signal, such as Go Tenna Mesh. Important: While other people’s phones are used to send a message, only the sender and the receiver are able to see the content of the message. The more phones you have, the further a message is able to travel. Basically, multiple phones create a path of communication. When turned on, the signal is able to piggyback from one cell phone to the next, until it reaches its intended destination. Some mesh messaging apps have a P2P mode. There is, however, a way to increase the distance a message is able to travel: through a peer-to-peer mode (P2P). You basically have to be at proximity to be able to communicate. Neither Bluetooth nor direct Wi-Fi allow for a wide range when trying to send messages between two phones. The range of a direct Wi-Fi connection is roughly about 200 feet, or 60 meters. Regular wireless networks typically use multihop communication. The wireless connection only exists between the two devices, which is why it’s also called a single-hop communication. Unlike a Wi-Fi signal you connect to from a router, direct Wi-Fi (sometimes also called ad-hoc Wi-Fi) is a limited connection that is created between two phones. The maximum range between devices is about 300 feet, or 100 meters. It’s the same technology when you use Bluetooth to transfer music or images from one device to another. Two devices are able to use Bluetooth to set up a secure peer-to-peer connection. Instead, they rely on Bluetooth or direct Wi-Fi connection. The off-grid messenger apps, also known as mesh messengers, don’t need access to public infrastructure like cell phone towers or internet to send messages from one phone to another. ![]() Offline messaging is a new trend in secure communication. ![]() What is offline messaging, and how does it work? ![]() Can offline messengers replace messaging apps? Spoiler: no!.From camping trips to political protests: when off-grid messaging comes in handy.What is offline messaging, and how does it work?.Offline messaging apps: send and receive texts without internet
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![]() Philadelphia (PA): AACR Cancer Res 2022 82(12_Suppl):Abstract nr 5641. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022 2022 Apr 8-13. Tumor cell intrinsic factors in colorectal cancer immune evasion. Furthermore, the functional role of these immune suppressive genes will be characterized using shAKPS mutant organoids and in vivo orthotopic CRC tumor models.Ĭitation Format: Dechen Wangmo, Xianda Zhao, Angelo Yuan, Travis Gates, Subree Subramanian. Our findings suggest that overexpression of immune suppressive genes in cancer cells may cause T cell dysfunction and exclusion in tumors. Our results show that these immune suppressive genes are overexpressed in tumor tissues, and negatively correlate with CD8 + T cell infiltration. Furthermore, we performed correlation tests to determine their role in immune cell infiltration and T cell dysfunction. To define their expression profile in the tumor, we performed TCGA data analysis in fourteen different cancer types. Using CRISPR/Cas9 screening and integrative immune score analysis, we identified potential immune evasive genes. The shAKPS tumoroids present key features of advanced CRC that are unresponsive to ICIs including invasive tumor, metastasis, and T cell exclusion. Addition of p53 -/- and Smad4 -/- mutations drives invasiveness and metastasis. Cancer immunotherapy microRNAs cancer genetics sarcoma colon cancer. We demonstrated that tumoroids with only shApc and Kras G12D mutations can form a solid tumor in two weeks. Professor, Department of Surgery, University of Minnesota. Therefore, we developed a tumor organoid (tumoroids) model system adapted from Jacks lab that harbors shApc, Kras G12D, p53 -/- and Smad4 -/- (shAKPS) mutations, which are co-mutated with high frequency and associated with poor prognosis. ![]() To elucidate the factors underlying ICI resistance, it is critical that preclinical models faithfully recapitulate the tumor physiology and genetics of the human disease. We hypothesize that targeting tumor-cell intrinsic factors can overcome T cell exclusion and will sensitize the tumor to ICIs. Therefore, it is crucial to characterize factors shaping immune evasion to improve the response to ICIs. However, most CRC lacks robust T-cell infiltration due to immune evasion mechanisms. ICIs preferentially have robust responses from tumors with pre-existing T cell infiltration. In the past decade, immune checkpoint inhibitors (ICIs) have been a major clinical breakthrough with promising clinical benefits in many cancer types, but its efficacy is limited in most (~85%) CRC patients. Although early detection through screening has reduced CRC incidence, the prognosis for metastatic CRC is poor. ![]() The poor response of most colorectal cancer (CRC) patients to immunotherapy is a major unmet clinical need. ![]() Iexplorer 4.2.0 keygen free.Serial iexplorer 4.2.0 free download.iExplorer 4.4 for Windows/ iEx Access Photos, Files and Everything Else With iExplorer, you can access more files and folders without modifying jailbreaking your device than ever before. Export iPhone Text Messages, SMS, iMessages, text messages iExplorer allows you to browse, preview, save, and export the most important information in the databases of your iPhone or iPad. Password Recovery Recover your password Your email.ĭescription Changelog Specifications. Sign Up Welcome! Register for an account Your email. Sign In Welcome! Log into your account Your username. Requires macOS It works with both 32 and 64 bit systems. ![]() Also you can access photos on your iPhone or iPod. With iExplorer, you can access more files and folders without modifying jailbreaking your device than ever before. Furthermore, you can view and save your voicemails, or export them to your Mac or PC. The beautiful, intuitive app interface lets you search and save iPhone text messages with ease. It allows you to remember special moments, preserve important data, and get more done across your devices with simple iPhone SMS backup. With iExplorer, you can keep any or all of your text messages easily. Everything is always just a couple of clicks away.īe in charge of your content. View your appointments, calendar events, and your call history. Or use the Auto Transfer feature and copy everything from your device to iTunes. With one click, iExplorer lets you instantly rebuild entire playlists. Then copy them to iTunes with the touch of a button or with drag and drop. You can search for and preview particular songs. You can use the easy drag-and-drop methods to add or remove files and folders from the iPhone.
This meant that the tires didn't properly fit the wheels. But there were too many differences so I went back to the 50cc rear wheel. I had sourced a rear wheel from the 2T 125 because it's wider. ![]() I've been running the "MotoGP" tires on this bike. I still haven't figured out how to make that happy, so for this temporary engine build I'm going to go with tho 40mm stroked Xtreme kit, also with the Airsal crank. The previous build featured the 45mm stroked Airsal Xtreme kit. It's really not the right match for my engine, but well it's a Jolly Moto! It got relisted, and still-so I bought it. One popped up on eBay a while back, and no one went for it. I have one on the Monza, and it's so awesome. I always wanted a Jolly Moto pipe for the GPR. I was able to get the forks! Yeah that's all I'm going to say about them for now, but Scotty knows what I'm talking about (and if you want a set let me know. Some fun things I've already picked up for it But being a long term project it's okay to do things in steps. That means a temporary engine, temporary plastics, and well a few of the things that I wanted to do. I was going to wait until I had all the bits, but I so miss this bike that I have to do something about it. This will very much be a project where the bike comes together, and then I slowly rebuild it to where I want to take it. I've slowly been gathering parts for it, and now I have enough to maybe get it running again. CA speak for I'm not paying any reg fees while I can't ride my bike. So I pulled it apart, brought it into the kitchen, and set it to non-op. I tried a few things to get it running again, but it really needed some serious effort. But I wasn't the only one hurt-my bike suffered greatly too. Even three years later I'm nowhere close to the physical state before the crash. This broke many of my bones, messed up my knee, and a bunch of rear teeth. Then almost exactly three years ago I was crashed on it by a young woman in a Honda Civic. Engine, brakes, suspension, tires-the only thing I didn't really mess with was the looks, because I really love the styling of the 05 GPR. The warehouse guys said "theres no way you are getting that in there." I just proceeded to prove him wrong. A Saab buddy of mine picked it up, crated it, and delivered it to a dock where it was then trucked out to Oakland. My all time favorite bike is the 05 GPR that I sourced from Atlanta. I'm starting with the most recent and working backwards. The photo hosting service PhotoBucket has gone psycho. Since the game is repetitive, most people think it would become boring. You can also bump into a traffic sign or wall and get caught by the inspector.īut not to worry, you can go back and start playing again. The round ends if you stumble twice and the inspector catches you, or you get hit by an upcoming train. Then, swipe right or left to move in any direction. Swipe down to roll underneath something or up to jump. To play the game, you simply swipe your screen. As you keep running, the game speeds up, making it harder to dodge obstacles. You must dodge the trains, the traffic signs, and more. ![]() Since this is a subway, there are different trains, many of which are still running. You cannot stop running and must avoid a lot of obstacles. It’s pretty easy to play this game, as it focuses on running nonstop o the railroad tracks. Once he blows his whistle, the gameplay begins. The inspector does not stop chasing him with his dog, focusing on teaching him a lesson. It starts with Jake (or any character you are playing with), who is painting graffiti on the train car.īut, the inspector catches him, and he has to run. Unlike most endless-run games, Subway Surfers follows the gameplay from beginning to end. The Subway Surfers APK MOD offers interesting gameplay, and the storyline backs this up. There are so many support items that you can purchase with your coins, and then you can get as many as you can with Subway Surfers unlimited coins. You can play with Jake, Tricky, Fresh, and other characters. The game offers amazing graphics and sound effects to support the interesting gameplay. You must avoid many things and prevent accidents, but you can never stop running. ![]() You can join the game in any country and run as fast as possible. The gameplay might seem repetitive as you keep on running, but you’ll have to stay on your toes so you don’t get caught while collecting rewards on the way. The game is so popular that it has a sequel and multiple spin-offs showing its characters in different countries. Subway Surfers can be seen as one of the best games with an endless-running theme. ![]() CoE butchers the combat mechanics for the sake of brevity.īoth of them are pretty fun, Dominions more so if you enjoy strategy and actual depth, keeping in mind once you develop cheese strategies, the AI will not put up any fight what so ever. The best way to describe differences between CoE and Dom to me is that, while in Dom you play a pretender, in CoE you play a Prophet (or Supercombatant, in the case of some factions).Ĭlick to expand.Dominions has infinitely more varied combat. ![]() A Lord playing in the Dark Ages has to be much more cautious in expansion, since castles are much rarer, while a Witch will find the Empire era more challenging since many swamps have been drained or filled-in. While in Dom eras tend to change the make-up of your factions (since the actual terrain part is handled by the Domain mechanic) in CoE eras considerably change your playstyle (factions remain the same). What seems like smarter AI is merely more choice-limited AI.Īnother part I like more about CoE is the era system. Since Dom is province-based and movement is much more restricted, the AI simply has fewer choices when pursuing expansion lanes. It's something which regularly happens in Heroes (M&M). The AI splits armies when attempting to take over stuff like mines (and swamps/ancient forests if it can use them). ![]() In your example, it may have considered your army wasn't powerful enough to defeat its main stack. CoE AI uses a weighting system for threats. ![]() TextWrangler works with Services, and the Tidy to XHTML service lets me take the not-quite-standards-compliant code that Claris Home Page produces and the much more compliant HTML code that KompoZer produces and convert them to XHTML in a flash. In addition to having TextWrangler search the current open page or the entire website, I can also have it search only the results of an earlier search (as with the TextSoap example) or only the files I currently have open. I need to have a tool that can go through the entire website and replace a misspelled name, change an updated URL, substitute a new email address for an old one, and locate links to websites I've learned no longer exist or have expired and been taken over with unrelated content. That's the primary reason I stuck with BBEdit 4.6 as long as I did – and why I was thrilled when Bare Bones made TextWrangler free. Then I did a search-and-replace to find '/textsoap.html' and substitute '/textsoap/', and after that I looked through the results page and found some links to mac_textsoap.html and textsoap_mac.html, which I also replaced. Then I did a search-and-replace on just those results, replacing 'textSOAP' with 'TextSoap' on one pass, and 'TextSOAP' on the next. The first step was to search all of our files for every instance of textsoap regardless of case. I also discovered that the URL had changed from to. Google does a great job of searching our content on the Web, and TextWrangler does a great job of searching the mirrored copy on my hard drive.įor instance, while writing my review of TextSoap, I discovered that it was no longer called textSOAP or TextSOAP. Low End Mac is composed of thousands of pages, and there's just no way to know where everything is. TextWrangler didn't become free until Bare Bones released TextWrangler 2, and for a lot of people, it's all the text editor you'll ever need. TextWranger 1 was a low cost alternative to BBEdit and supposedly replaced BBEdit Lite for OS X users. The undisputed king of text editors on the Mac is Bare Bones Software's BBEdit, which sells for $125 ($49 for education users).įor those who need a bit less or can't afford BBEdit, Bare Bones offers the free TextWrangler 2 program. Quit BBEdit/TextWrangler if they're running, then switch to. Thanks to Mac OS X Hints readers CkBCowboy and Mark Johnson, however, you can actually customize the colors of these characters. The most popular Mac alternative is Visual Studio Code, which is both free and Open Source.If that doesn't suit you, our users have ranked more than 50 alternatives to TextWrangler and many of them are available for Mac so hopefully you can find a suitable replacement. There are many alternatives to TextWrangler for Mac and since it's discontinued a lot of people are looking for a replacement. TextWrangler's best-of-class features include 'grep' (regular-expression) pattern matching, search and replace across multiple files, function navigation and syntax coloring for numerous source code languages, code folding, FTP and SFTP open and save, AppleScript, Mac OS. ![]() Among its other useful features, it also has a programming mode. Mac OS X - English TextWrangler has been developed by Bare Bones in which the user is able to edit texts. It lets you see the code you're working on using a single typeface, and the best text editors use color coding to help you distinguish tags from content. It doesn't let you play with fonts or color or styles. It lets you play with fonts, type size, boldface and italic – all the tools you need to write a short story, a novel, an essay, a review, whatever.įor creating code, the ideal tool is a text editor. 2007 – For writing at your computer, the ideal tool is word processing software. You can tweak things like Orbital Speed, Life Span, Color Entropy and Zoom & Blur, and you’ll notice that modifying these parameters really changes what’s displayed on screen. Visual effects are obviously Muon’s main feature, and interestingly enough the app comes with settings to control the Audio, Drag and Mutate reactions of the Visualizer. You can tap on a song’s name at any time to change artist or album or pick a playlist, but I don’t like the blue design of the music picker menu. The app can fetch songs from your existing Music library, and displays AirPlay-compatible controls as a translucent bar at the bottom. That said, Muon is a nice music visualizer for the iPad, kind of like iTunes’ own visualizer but with more effects and touch controls. I don’t manage advertising on MacStories anymore, so the encounter was completely random, and the fact that the developers are advertising on our site didn’t influence my decision to mention their iPad app on the Journal. I found out about Muon when I first saw an ad in our site’s sidebar. ![]() Sounds cool? Follow us for this week’s app collection after the break, and stay tuned for more App Journals in the next weeks. While we wait for the craziness to begin later this month, we take a look at a cool music visualizer for the iPad, a finance app for the iPhone, a Campfire client and a utility to update your status on multiple social networks at once. ![]() App Journal is a new series aimed at showcasing apps we have enjoyed using on our iPhones, iPads, and Macs, but decided not to feature in a standalone, lengthy review here on MacStories. App Journal is a mix of classic reviews, weekly app recommendations, and a diary of our experiences with apps that still deserve a proper mention.Īfter the release of iOS 5, iCloud and the first wave of new apps that take advantage of Apple’s new OS and sync services, the App Store is quickly marching towards a holiday season that will be huge, both for hardware sales as well as app and game releases, software deals, and new retail features at Apple’s physical stores. Vector. ![]() Royalty-Free (RF) Alarm Clock Clipart and Illustrations 1. 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